Natural History of Pediatric Low-Grade Glioma Disease - First Multi-State Model Analysis
نویسندگان
چکیده
منابع مشابه
Targeted therapy in pediatric low-grade glioma.
Collectively, pediatric low-grade gliomas account for most brain tumors reported in children. Surgery is typically curable for operable lesions. However, more effective therapies are required for inaccessible tumors, both to overcome refractory disease and to minimize the toxicity associated with conventional adjuvant chemotherapy and radiotherapy regimens. Recent years have witnessed rapid imp...
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INTRODUCTION Pediatric high-grade gliomas are rare tumors with poor outcomes and incompletely defined management. We conducted a multi-institutional retrospective study to evaluate association of clinical, pathologic, and treatment characteristics with outcomes. MATERIALS AND METHODS Fifty-one patients treated from 1984 to 2008 at the Ohio State University or University of Michigan were inclu...
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The optimal management of patients with low-grade glioma (LGG) is controversial. The controversy largely stems from the lack of well-designed clinical trials with adequate follow-up to account for the relatively long progression-free survival and overall survival of patients with LGG. Nonetheless, the literature increasingly suggests that expectant management is no longer optimal. Rather, there...
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BACKGROUND To retrospectively assess feasibility and toxicity of proton therapy in patients with low-grade glioma (WHO °I/II). PATIENTS AND METHODS Proton beam therapy only administered in 19 patients (median age 29 years; 9 female, 10 male) for low-grade glioma between 2010 and 2011 was reviewed. In 6 cases proton therapy was performed due to tumor progression after biopsy, in 8 cases each d...
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A differential analysis framework of longitudinal FLAIR MRI volumes is proposed, based on non-linear gray value mapping, to quantify low-grade glioma growth. First, MRI volumes were mapped to a common range of gray levels via a midway-based histogram mapping. This mapping enabled direct comparison of MRI data and computation of difference maps. A statistical analysis framework of intensity dist...
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ژورنال
عنوان ژورنال: Journal of Cancer
سال: 2019
ISSN: 1837-9664
DOI: 10.7150/jca.33463